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FHAIVE is part of the Faculty of Medicine and Health Technology (MET), Tampere University, Finland.


Primacyt cooperates with FHaive, formerly known as FICAM, and is now the Finnish Center for Alternate Methods, the Hub for Development and Validation of Integrated Approaches.

FHAIVE is a research institute devoted to the development and validation of integrated approaches (IATA). IATA allow new knowledge to be gathered, concerning the chemical-biological systems interactions. In FHAIVE, IATA are developed by integrating advanced in vitro models with toxicogenomics and AI-enabled advanced data modelling.

FHAIVE's multidisciplinary expertise includes developing human cell-based methods for regulatory toxicology, mechanistic toxicology, cell biology, tissue technology, selected disease models, and cell imaging processes.

Primacyt and FHAIVE are ideally aligned on in-vitro methods focused on research and development under strict conformity to the GLP regulations. The cooperation is a milestone in tests for epidermal skin corrosion tests (OECD TG 431), epidermal skin irritation test (OECD TG 439) and service for testing acute toxicity.

The expansion of services at Primacyt will result in joint growth of the market and marketing presence in Southern and Central Europe. For our customers, the inclusion of tissue and organ models improve efficacy and safety tests of drugs, safety tests of industrial chemicals, and cosmetic ingredients, as well as for agrochemicals, food additives, and biocides.
FHAIVE's multidisciplinary expertise includes developing human cell-based methods for regulatory toxicology, mechanistic toxicology, cell biology, tissue technology, selected disease models, and cell imaging processes.
Primacyt and FHAIVE are ideally aligned on in-vitro methods focused on research and development under strict conformity to the GLP regulations. The cooperation is a milestone in tests for epidermal skin corrosion tests (OECD TG 431), epidermal skin irritation test (OECD TG 439) and service for testing acute toxicity.
The expansion of services at Primacyt will result in joint growth of the market and marketing presence in Southern and Central Europe. For our customers, the inclusion of tissue and organ models improve efficacy and safety tests of drugs, safety tests of industrial chemicals, and cosmetic ingredients, as well as for agrochemicals, food additives, and biocides.

For the three tests below, Primacyt is the exclusive Partner for Germany, Switzerland and Austria. Primacyt is prepared to take care for all other European countries with the exception of Finland, Sweden, Estonia, Lithuania and Latvia. Primacyt is also available to customers in Asia Pacific.


Epiderm (TM)
Skin Corrosion Test
(OECD TG 431)


Skin corrosion testing is in compliance with OECD TG 431 using EpiDerm™ tissue by MatTek Corporation.
Customers have the option for GLP and non-GLP testing services., whereby the test chemicals are applied for 2 or 60 minutes.

The potential for skin corrosion tests includes, but is not limited to:
  • Human skin models.
  • Classification of corrosive materials.
  • Determination of hazard potentials.
  • In vitro membrane barrier test for skin corrosion.
  • Resolution of cross-resistance between unrelated and related drugs.
  • Measurement of Sensitivity of novel drugs.
  • Measurement of drug sensitivity ex vivo for the prediction of clinical results.
  • Drug screening and testing of cell lines or patient samples.



Epiderm (TM)
Skin Irritation Test
(OECD TG 439)


Skin Irritation Testing is very similar to Corrosion Testing with regard to GLP/non-GLP options. Skin irritation is defined as production of reversible damage (local inflammatory reaction) to the skin following the application of a test chemical for 60 minutes.

The EpiDerm(TM) skin irritation test is performed using human cell based three-dimensional highly differentiated keratinocyte cultures (EpiDerm) in compliance with OECD TG 439. The potential of chemicals to induce skin irritation is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals.

Applications comprise efficacy and safety testing of pharmaceuticals, safety testing of industrial chemicals, cosmetic ingredients, agrochemicals, food additives, and biocides.



In vitro
Testing of
Acute Toxicity


Acute toxicity services comprise pharmaceuticals, cosmetics, biocides, industry chemicals and more. Our services allow the prediction of the acute toxicity of chemicals in line with the other testing possibilities. The methods are suited to determine the starting dose for acute oral toxicity tests in rodents.
We offer
  • BALB 3T3 / Neutral Red Uptake Assay (OECD GD 129,
  • Human BJ fibroblast / Neutral Red Uptake Assay (intra - laboratory validated),
  • Other endpoints and cell types upon requests.
  • Our customers can expect support in result analysis and the option of GLP or non-GLP testing.
  • Cytotoxicity testing uses eight different concentrations and negative controls in each test, all suitable for soluble test items.


Epiderm (TM)
Skin Corrosion Test
(OECD TG 431)


Skin corrosion testing is in compliance with OECD TG 431 using EpiDerm™ tissue by MatTek Corporation.
Customers have the option for GLP and non-GLP testing services., whereby the test chemicals are applied for 2 or 60 minutes.

The potential for skin corrosion tests includes, but is not limited to:
  • Human skin models.
  • Classification of corrosive materials.
  • Determination of hazard potentials.
  • In vitro membrane barrier test for skin corrosion.
  • Resolution of cross-resistance between unrelated and related drugs.
  • Measurement of Sensitivity of novel drugs.
  • Measurement of drug sensitivity ex vivo for the prediction of clinical results.
  • Drug screening and testing of cell lines or patient samples.




Epiderm (TM)
Skin Irritation Test
(OECD TG 439)


Skin Irritation Testing is very similar to Corrosion Testing with regard to GLP/non-GLP options. Skin irritation is defined as production of reversible damage (local inflammatory reaction) to the skin following the application of a test chemical for 60 minutes.

The EpiDerm(TM) skin irritation test is performed using human cell based three-dimensional highly differentiated keratinocyte cultures (EpiDerm) in compliance with OECD TG 439. The potential of chemicals to induce skin irritation is an important consideration in establishing procedures for the safe handling, packing and transport of chemicals.

Applications comprise efficacy and safety testing of pharmaceuticals, safety testing of industrial chemicals, cosmetic ingredients, agrochemicals, food additives, and biocides.




In vitro
Testing of
Acute Toxicity


Acute toxicity services comprise pharmaceuticals, cosmetics, biocides, industry chemicals and more. Our services allow the prediction of the acute toxicity of chemicals in line with the other testing possibilities. The methods are suited to determine the starting dose for acute oral toxicity tests in rodents.
We offer
  • BALB 3T3 / Neutral Red Uptake Assay (OECD GD 129,
  • Human BJ fibroblast / Neutral Red Uptake Assay (intra - laboratory validated),
  • Other endpoints and cell types upon requests.
  • Our customers can expect support in result analysis and the option of GLP or non-GLP testing.
  • Cytotoxicity testing uses eight different concentrations and negative controls in each test, all suitable for soluble test items.